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KMID : 0878220020140030114
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Journal of Sasang Constitutional Medicine
2002 Volume.14 No. 3 p.114 ~ p.131
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The Effect of Chungpyesagantang on Lipopolysaccharide induced Arthritis in Mice
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Park Seong-Sik
Kim Ju-Hee
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Abstract
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1.PURPOSE : The purpose of this study is to investigate the effect of Chungpyesagantang on LPS induced Arthritis in Mice.
2.METHOD : All the BALB/C Mice used in this study were 4wks of age at the start of the experiment. The experimental model of Arthritis was induced by injectection of 300㎍/kg LPS in mice knee joint. The experiment was compare daily CS treatment group after Arthritis elicitation with Arthritis elicitated group at day 4, 7, 14 after Arthritis elicitation.
3.RESULTS : 1) The hyperplasia of synoviocytes of CS treatment group after Arthritis elicitation is soften than Arthritis elicitated group. 2) The aggregation of collagen fibers CS treatment group after Arthritis elicitation is decreased than Arthritis elicitated group. 3) The distribution of TUNEL positive cells(apoptotic cell) of CS treatment group was remarkably increased than Arthritis elicitated group. 4) The distribution of TNF-α, NF-κB p50, COX-2 positive cells of CS treatment group after Arthritis elicitation in synovial membrane was decreased than Arthritis elicitated group. 5) The distribution of IL-2R-α, ICAM-1 positive cells of CS treatment group after Arthritis elicitation in apical surface of synovial membrane was decreased than Arthritis elicitated group. 6) The distribution of NF-κB p50, IL-2R-α in common iliac lymph node of CS treatment group after Arthritis elicitation positive cells was decreased than Arthritis elicitated group.
4.CONCLUSION : As a result of these experimental results, it may be concluded that Chungpyesagantang used for treatment of LPS induced Arthritis in Mice. Inflamation activity in CS treatment group after Arthritis elicitation was decreased than Arthritis elicitated group.
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KEYWORD
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Chungpyesagantang, LPS induced Arthritis, TNF-α, $NF-{\kappa}B\, p50$, COX-2, IL-2R-α, ICAM-1
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